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Again, this impairment can be effectively bypassed by supplementation with gamma-glutamylcysteine (GGC) which can be transported into cells where it will be rapidly converted to glutathione by the enzyme Glutathione Synthase (GS)

Arthroscopy 31 , 16801687 (2015)

This heterogeneous condition was finally named as Laron Syndrome or primary Growth Hormone insensitivity (GHI), and it includes: GH receptor deficiency (the most common), GH-GH receptor signal transduction defect, IGF-I synthetic defect, IGF-I receptor deficiency and IGF-I/IGF-I receptor signal transduction defects